Top Hotels in South San Francisco Area

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Nestled just north of the bustling heart of Silicon Valley, South San Francisco, a hidden gem in the Bay Area, offers travelers a unique blend of industrial innovation and serene suburban charm. With its convenient location, South San Francisco serves as an ideal base for exploring the wider San Francisco Bay Area, offering easy access to both downtown SF and Silicon Valley, all while providing a quieter, more relaxed setting to retreat to after a day of exploration.

The hotels in South San Francisco range from luxurious suites with stunning city views to budget-friendly inns that don't compromise on comfort or convenience. Each establishment prides itself on providing exceptional service, ensuring that every guest's stay is comfortable, enjoyable, and memorable. For those looking to immerse themselves in the local culture, some hotels even offer unique experiences, such as guided tours or dining options that showcase the rich culinary landscape of Northern California.

Choosing the right hotel can significantly enhance your travel experience, making it crucial to consider your accommodation options carefully. This article aims to shed light on the top hotels in South San Francisco, presenting a curated list that caters to a wide range of preferences and budgets. Whether you're in town for business, a romantic getaway, or a family vacation, South San Francisco has a hotel that's perfect for you, blending convenience, comfort, and access to all the area has to offer.

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Our Top 6

(Sorted by rating & number of reviews)

1. La Quinta By Wyndham San Francisco Airport North Hotel
2. Ac Hotel By Marriott San Francisco Airport/Oyster Point Waterfront
3. Ac Hotel By Marriott San Francisco Airport/Oyster Point Waterfront
4. Hotel Focus Sfo
5. Hilton Garden Inn San Francisco Airport North
6. Holiday Inn Express San Francisco Airport North, An Ihg Hotel

Luxury Hotels in South San Francisco

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South San Francisco
Sep 16, 2025 - Sep 17, 2025

La Quinta By Wyndham San Francisco Airport North Hotel

7.7

Good

(1465 Reviews)

+ 119 photos
La Quinta Inn by Wyndham provides an excellent balance between affordability and comfort. Guests can enjoy complimentary breakfast, free Wi-Fi, and a shuttle service to the nearby San Francisco International Airport, making it a convenient choice for travelers. The rooms are clean, comfortable, and equipped with all the necessary amenities for a pleasant stay, including a coffeemaker, hairdryer, and ironing facilities. The outdoor pool is a welcome bonus for relaxation after a day of exploring. This hotel stands out for offering affordable accommodations without compromising on quality or convenience, making it an attractive option for budget-savvy travelers in South San Francisco.
Address: 20 Airport Boulevard
Rating: Good 7.7 (1465 Reviews)
Rooms: 171
Price: From 70$

Ac Hotel By Marriott San Francisco Airport/Oyster Point Waterfront

8.7

Good

(395 Reviews)

+ 76 photos
This all-suite hotel is ideal for families seeking the comforts of home while traveling. Each suite comes with a fully equipped kitchen, separate living and sleeping areas, and free Wi-Fi, providing space and convenience for the whole family. The hotel offers a complimentary breakfast, an indoor pool, and a fitness center. Its location near the Oyster Point Waterfront allows families to explore the outdoors easily. The Residence Inn's spacious accommodations and family-friendly amenities make it a top choice for those visiting South San Francisco.
Address: 1333 Veterans Boulevard
Rating: Good 8.7 (395 Reviews)
Rooms: 187
Price: From 197$

Business-Friendly Hotels in South San Francisco

South San Francisco, with its proximity to Silicon Valley and San Francisco's financial district, is a prime location for business travelers. Recognizing this, certain hotels in South San Francisco have tailored their offerings to meet the needs of the modern business traveler, combining convenience, function, and comfort. These establishments provide versatile meeting spaces, high-speed internet access, and comfortable workstations, among other amenities. The following hotels stand out not just for their facilities but also for their commitment to making every business trip seamless and productive.

Ac Hotel By Marriott San Francisco Airport/Oyster Point Waterfront

8.7

Good

(395 Reviews)

+ 76 photos
Nestled on the scenic waterfront, the AC Hotel by Marriott combines modern European elegance with the unique Northern Californian vibe. This hotel effortlessly bridges the gap between luxury and simplicity, offering a refined environment that appeals to both leisure and business travelers. Guests can enjoy thoughtfully designed rooms with panoramic views of the San Francisco Bay, indulge in Spanish-inspired cuisine at the on-site restaurant, and take advantage of the state-of-the-art fitness center. The stylishly appointed meeting spaces make it an ideal choice for those seeking a luxury venue for business events. Its proximity to the airport, coupled with a serene waterfront setting, makes the AC Hotel a standout option for guests looking for sophistication and convenience in South San Francisco.
Address: 1333 Veterans Boulevard
Rating: Good 8.7 (395 Reviews)
Rooms: 187
Price: From 197$

Hotel Focus Sfo

7.2

Good

(221 Reviews)

+ 135 photos
Hotel Focus SFO is designed with the budget traveler in mind, offering a no-fuss, comfortable stay experience. Amenities include free Wi-Fi, complimentary continental breakfast, and a shuttle service to the San Francisco Airport. The rooms, while straightforward, are clean and feature modern comforts like flat-screen TVs and coffee makers. This hotel is an ideal pick for travelers who want a simple, cost-effective base in South San Francisco, with easy access to the city and beyond.
Address: 111 Mitchell Avenue
Rating: Good 7.2 (221 Reviews)
Rooms: 117
Price: From 88$

Budget-Friendly Hotels in South San Francisco

For travelers keeping an eye on their expenses without wanting to compromise on quality, South San Francisco offers several budget-friendly hotels. These establishments prove that affordability doesn't mean a downgrade in cleanliness, safety, or comfort. They are strategically located with access to local attractions and transport links, ensuring guests can explore the area without breaking the bank. The selected hotels in this section are perfect for travelers who prioritize value, from families to backpackers and everyone in between.

Hilton Garden Inn San Francisco Airport North

8.0

Good

(392 Reviews)

+ 81 photos
The Hilton Garden Inn offers a blend of luxury and comfort, making it a perfect choice for travelers who appreciate attention to detail and outstanding service. This hotel boasts spacious, elegantly furnished rooms and suites equipped with modern amenities, designed to provide a comfortable and luxurious stay. Guests can enjoy fine dining at the on-site restaurant, stay fit in the fully equipped fitness center, or relax in the beautifully landscaped outdoor areas. The Hilton Garden Inn also provides versatile meeting spaces, offering a sophisticated backdrop for corporate events and private gatherings. With its blend of luxury amenities and a commitment to exceptional service, this hotel is a premier choice for those seeking upscale accommodations in South San Francisco.
Address: 670 Gateway Blvd
Rating: Good 8.0 (392 Reviews)
Rooms: 169
Price: From 212$

Holiday Inn Express San Francisco Airport North, An Ihg Hotel

7.4

Good

(488 Reviews)

+ 71 photos
This hotel is a favorite for budget-conscious travelers who still seek the comfort and amenities of a higher-end establishment. The Holiday Inn Express near the San Francisco Airport North offers complimentary breakfast, high-speed internet, and a free airport shuttle service. The rooms are designed with modern decor and equipped with work desks and flat-screen TVs, catering to both business and leisure travelers. Fitness enthusiasts will appreciate the 24-hour gym. Its location, service, and amenities make it an excellent choice for those looking for value in South San Francisco.
Address: 373 South Airport Boulevard
Rating: Good 7.4 (488 Reviews)
Rooms: 89
Price: From 115$

Family-Friendly Hotels in South San Francisco

Traveling with family involves finding accommodations that cater to the needs of all ages, from toddlers to grandparents. Hotels in South San Francisco that are deemed family-friendly offer amenities such as spacious rooms or suites, on-site dining with kid-friendly menus, and proximity to local parks and attractions. The hotels highlighted in this section ensure that families have a comfortable, enjoyable stay, making their trip memorable for all the right reasons.